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Cover Feature: Enhancement of Peroxidase Activity in Artificial Mimochrome VI Catalysts through Rational Design (ChemBioChem 17/2018)
Author(s) -
Caserta Giorgio,
Chino Marco,
Firpo Vincenzo,
Zambrano Gerardo,
Leone Linda,
D'Alonzo Daniele,
Nastri Flavia,
Maglio Ornella,
Pavone Vincenzo,
Lombardi Angela
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800453
Subject(s) - catalysis , heme , peroxidase , cover (algebra) , molecule , chemistry , catalytic efficiency , combinatorial chemistry , stereochemistry , organic chemistry , engineering , enzyme , mechanical engineering
The cover feature picture shows balls enclosing two artificial heme peroxidases. The cracked crystal ball and the steel ball symbolize the different features of the two molecules. A previous catalyst (FeMC6*), which suffered from bleaching during catalysis, was made more robust and active by inserting 2‐aminoisobutyric acid residues (Aib), thus giving rise to a new molecule (FeMC6*a) with improved catalytic behavior. The Aib residues are painted inside a set of gear wheels to signify their importance for catalyst function and stability. More information can be found in the communication by A. Lombardi et al. on page 1823 in Issue 17, 2018 (DOI: 10.1002/cbic.201800200).