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Analysis of Interactions between Telomeric i‐Motif DNA and a Cyclic Tetraoxazole Compound
Author(s) -
Sedghi Masoud Shadi,
Yamaoki Yudai,
Ma Yue,
Marchand Adrien,
Winnerdy Fernaldo Richtia,
Gabelica Valérie,
Phan Anh Tuân,
Katahira Masato,
Nagasawa Kazuo
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800425
Subject(s) - motif (music) , dna , stereochemistry , computational biology , chemistry , genetics , biology , combinatorial chemistry , nanotechnology , materials science , physics , acoustics
The interaction of a macrocyclic tetraoxazole compound, L2H2‐4OTD ( 1 ), with two aminoalkyl side chains and telomeric i‐motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i‐motif structure at two preferred binding sites.