Premium
Cover Feature: Bioorthogonally Applicable Fluorescence Deactivation Strategy for Receptor Kinetics Study and Theranostic Pretargeting Approaches (ChemBioChem 16/2018)
Author(s) -
van der Wal Steffen,
de Korne Clarize M.,
Sand Laurens G. L.,
van Willigen Danny M.,
Hogendoorn Pancras C. W.,
Szuhai Karoly,
van Leeuwen Fijs W. B.,
Buckle Tessa
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800403
Subject(s) - cover (algebra) , chemistry , pretargeting , biophysics , kinetics , quenching (fluorescence) , receptor , membrane , fluorescence , nanotechnology , biochemistry , materials science , biology , engineering , physics , immunology , mechanical engineering , radioimmunotherapy , quantum mechanics , antibody , monoclonal antibody
The cover feature picture shows a novel imaging‐based deactivatable concept that allows the screening of membrane receptors and their applicability in receptor‐(pre‐)targeted theranostics. Here click chemistry induces specific fluorescence‐quenching on the cell membrane, thereby allowing discrimination between membrane‐bound and internalized receptor–tracer complexes. More information can be found in the full paper by T. Buckle et al. on page 1758 in Issue 16, 2018 (DOI: 10.1002/cbic.201800229). Cover design: Sven van Leeuwen.