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Cover Feature: Peptide Nucleic Acid Conjugated with Ruthenium‐Complex Stabilizing Double‐Duplex Invasion Complex Even under Physiological Conditions (ChemBioChem 15/2018)
Author(s) -
Hibino Masaki,
Aiba Yuichiro,
Watanabe Yoshihito,
Shoji Osami
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800364
Subject(s) - peptide nucleic acid , ruthenium , duplex (building) , dna , conjugated system , conjugate , nucleic acid , chemistry , peptide , combinatorial chemistry , biochemistry , biophysics , stereochemistry , biology , organic chemistry , catalysis , polymer , mathematical analysis , mathematics
The cover feature picture shows direct DNA recognition of a peptide nucleic acid (PNA) conjugate–Ru complex (Ru‐PNA) by double duplex invasion. As Ru‐PNA is anchored to DNA by the additional interaction of the Ru complex with DNA, Ru‐PNA forms a more stable duplex with DNA. This higher DNA binding affinity enhances the invasion efficiency even at physiological salt concentrations. More information can be found in the communication by Y. Aiba, O. Shoji, et al. on page 1601 in Issue 15, 2018 (DOI: 10.1002/cbic.201800256).