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Front Cover: Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes (ChemBioChem 15/2018)
Author(s) -
Ganley Jack G.,
Carr Gavin,
Ioerger Thomas R.,
Sacchettini James C.,
Clardy Jon,
Derbyshire Emily R.
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800362
Subject(s) - serratia , front cover , biology , gene cluster , antimicrobial , antiparasitic , microbiology and biotechnology , swarming (honey bee) , bacteria , cover (algebra) , genetics , pseudomonas , mechanical engineering , engineering , medicine , pathology
The front cover picture shows Stephensiolide F, a cycliclipodepsipeptide produced by a Serratia sp. within Anopheles mosquitoes, with the corresponding HMBC NMR spectrum in the background. We determined the structures of eleven stephensiolides with NMR and MS/MS techniques. Stephensiolides were shown to facilitate bacteria swarming motility in addition to having antibiotic and antiparasitic activity. The biosynthetic gene cluster of the stephensiolides was identified, and sequence analysis suggests it is dispersed in Serratia spp. isolated from different ecological niches. More information can be found in the communication by J. Clardy, E. R. Derbyshire, et al. on page 1590 in Issue 15, 2018 (DOI: 10.1002/cbic.201800124).