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Cover Feature: A Forkhead Box Protein C2 Inhibitor: Targeting Epithelial–Mesenchymal Transition and Cancer Metastasis (ChemBioChem 13/2018)
Author(s) -
Castaneda Maria,
Chen Luxi,
Pradhan Lagnajeet,
Li Shichang,
Zein Ruba,
Lee Yeongju,
Lim HyunSuk,
Nam HyunJoo,
Lee Jiyong
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800300
Subject(s) - epithelial–mesenchymal transition , cover (algebra) , metastasis , feature (linguistics) , cancer research , cancer , cancer metastasis , chemistry , biology , genetics , engineering , mechanical engineering , linguistics , philosophy
The cover feature picture shows MC‐1‐F2, the first small‐molecule inhibitor of forkhead box protein C2 (FOXC2). FOXC2 is known to be necessary for initiating and maintaining the epithelial–mesenchymal transition (EMT), a critical process of cancer metastasis. A bicycle with square wheels illustrates the cancer cells whose metastatic move was halted due to the reversal of EMT by MC‐1‐F2. More information can be found in the communication by J. Lee et al. on page 1359 in Issue 13, 2018 (DOI: 10.1002/cbic.201800022).