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Highly Efficient Cell‐Penetrating Probes of Protein Arginine Deiminases for Functional Proteomics
Author(s) -
Kumar Sanjai
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800257
Subject(s) - drug discovery , proteomics , computational biology , drug development , arginine , biology , chemistry , bioinformatics , drug , biochemistry , amino acid , pharmacology , gene
Protein arginine deiminases (PADs) have recently emerged at the forefront of drug‐discovery programs for several human disorders. Despite this, a precise understanding of their functional roles in human biology remains to be fully elucidated. This report highlights a recent development of next‐generation activity‐based PAD probes that are highly efficient, cell active, and metabolically stable. This discovery should rapidly expedite functional assignments of PAD biology in both normal and diseased cells, thereby leading to the development of PAD‐targeted therapeutics in the near future.