A Glutathione‐Responsive Short Sequence of Metal–Organic Complex Array | Zendy

Bose Purnandhu | Zendy; Takei Toshiaki | Zendy; Li Xianglan | Zendy; Minowa Takashi | Zendy; Rajmohan Rajamani | Zendy; Vairaprakash Pothiappan | Zendy; Tashiro Kentaro | Zendy

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A Glutathione‐Responsive Short Sequence of Metal–Organic Complex Array

Author(s) -

Bose Purnandhu,

Takei Toshiaki,

Li Xianglan,

Minowa Takashi,

Rajmohan Rajamani,

Vairaprakash Pothiappan,

Tashiro Kentaro

Publication year - 2018

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201800252

Subject(s) - glutathione , chemistry , sequence (biology) , metal , dna , polymerization , stereochemistry , supramolecular chemistry , salt (chemistry) , biophysics , biochemistry , crystallography , biology , organic chemistry , polymer , enzyme , crystal structure

A short metal–organic complex array (MOCA) containing a sequence of RPtRRu ( 1 Cl ) was found to exhibit unique responses to a major biothiol, glutathione (GSH). Upon binding of GSH to 1 Cl , the resultant 1:1 complex ( 1 GS ) formed nanofibrous assemblies that suggested supramolecular polymerization through the double‐salt‐bridge structure formation. The binding behavior of this MOCA sequence to calf thymus DNA was also dependent on GSH; a larger conformational change of DNA was observed upon binding with 1 GS , relative to that with 1 Cl .

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