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A Glutathione‐Responsive Short Sequence of Metal–Organic Complex Array
Author(s) -
Bose Purnandhu,
Takei Toshiaki,
Li Xianglan,
Minowa Takashi,
Rajmohan Rajamani,
Vairaprakash Pothiappan,
Tashiro Kentaro
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800252
Subject(s) - glutathione , chemistry , sequence (biology) , metal , dna , polymerization , stereochemistry , supramolecular chemistry , salt (chemistry) , biophysics , biochemistry , crystallography , biology , organic chemistry , polymer , enzyme , crystal structure
A short metal–organic complex array (MOCA) containing a sequence of RPtRRu ( 1 Cl ) was found to exhibit unique responses to a major biothiol, glutathione (GSH). Upon binding of GSH to 1 Cl , the resultant 1:1 complex ( 1 GS ) formed nanofibrous assemblies that suggested supramolecular polymerization through the double‐salt‐bridge structure formation. The binding behavior of this MOCA sequence to calf thymus DNA was also dependent on GSH; a larger conformational change of DNA was observed upon binding with 1 GS , relative to that with 1 Cl .