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Roles of Albumin‐Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery
Author(s) -
Zhao Pengfei,
Wang Yonghui,
Wu Aihua,
Rao Yuefeng,
Huang Yongzhuo
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800201
Subject(s) - albumin , drug delivery , stromal cell , targeted drug delivery , cancer cell , cancer , transporter , metastasis , cancer research , drug , chemistry , biochemistry , biology , pharmacology , microbiology and biotechnology , medicine , gene , organic chemistry
Nutrient transporters have attracted significant attention for their promising application in biomimetic delivery. Due to the active consumption of nutrients, cancer cells generally overexpress nutrient transporters to meet their increased need for energy and materials. For example, albumin‐binding proteins (ABPs) are highly overexpressed in malignant cells, stromal cells, and tumor vessel endothelial cells responsible for albumin uptake. ABP (e.g., SPARC) is a promising target for tumor‐specific drug delivery, and albumin has been widely used as a biomimetic delivery carrier. Apart from the transportation function, ABPs are closely associated with neoplasia, invasion, and metastasis. Herein, a summary of the roles of ABP in cancer progression and the application of albumin‐based biomimetic tumor‐targeted delivery through the ABP pathway is presented.