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Cover Feature: Clickable Polyamine Derivatives as Chemical Probes for the Polyamine Transport System (ChemBioChem 9/2018)
Author(s) -
Vanhoutte Roeland,
Kahler Jan Pascal,
Martin Shaun,
van Veen Sarah,
Verhelst Steven H. L.
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800190
Subject(s) - polyamine , cover (algebra) , chemistry , feature (linguistics) , click chemistry , combinatorial chemistry , biochemistry , computer science , biophysics , nanotechnology , biology , materials science , engineering , mechanical engineering , linguistics , philosophy
The cover feature picture shows how an azido‐functionalized polyamine, clicked to a fluorphore, can be used as a tool to hijack the polyamine transport system (PTS). This opens the way to selectively deliver the fluorphore cargo into cancer cells, but not to non‐cancerous cells, which have lower activity of the PTS. More information can be found in the communication by S. H. L. Verhelst et al. on page 907 in Issue 9, 2018 (DOI: 10.1002/cbic.201800043).