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Cover Feature: Structural Diversity and Anticancer Activity of Marine‐Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer (ChemBioChem 8/2018)
Author(s) -
AlAwadhi Fatma H.,
Paul Valerie J.,
Luesch Hendrik
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800138
Subject(s) - elastase , cover (algebra) , feature (linguistics) , chemistry , cancer , computational biology , biochemistry , cancer research , biology , microbiology and biotechnology , enzyme , genetics , mechanical engineering , linguistics , philosophy , engineering
The cover feature picture shows cyclodepsipeptides, the producing marine cyanobacterium overgrowing a coral, and the compounds’ anticancer effects. Cyclodepsipeptides inhibit human neutrophil elastase and, as a consequence, the migration of invasive breast cancer cells through the modulation of gene expression and proteolytic processing of membrane proteins. More information can be found in the full paper by H. Luesch et al. on page 815 in Issue 8, 2018 (DOI: 10.1002/cbic.201700627).