Premium
Front Cover: Alkoxy Tetrazine Substitution at a Boron Center: A Strategy for Synthesizing Highly Fluorogenic Hydrophilic Probes (ChemBioChem 6/2018)
Author(s) -
Wu Min,
Wu Xiaoai,
Wang Yayue,
Gu Lei,
You Jiao,
Wu Haoxing,
Feng Ping
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800102
Subject(s) - tetrazine , bioorthogonal chemistry , bodipy , front cover , alkoxy group , chemistry , combinatorial chemistry , nanotechnology , boron , cover (algebra) , fluorescence , solubility , materials science , click chemistry , organic chemistry , alkyl , physics , mechanical engineering , quantum mechanics , engineering
The front cover picture shows the generation of BODIPY turn‐on probes by introducing alkoxy tetrazines at the boron center of the BODIPY scaffold. This method endows the probes with the high water solubility and endows the bioorthogonal partner—TCO— with strongly fluorogenic properties. Using designed probes to detect TCO‐decorated antibodies on cells provides further insights into their application in live‐cell imaging. More information can be found in the full paper by H. Wu, P. Feng, et al. on page 530 in Issue 6, 2018 (DOI: 10.1002/cbic.201700556).