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Reconfigurable DNA Nanoswitches for Graphical Readout of Molecular Signals
Author(s) -
Chandrasekaran Arun Richard
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800057
Subject(s) - dna , graphical display , agarose , biosensor , biophysics , macromolecule , biological system , pixel , computational biology , nanotechnology , chemistry , computation , computer science , biology , biochemistry , materials science , artificial intelligence , algorithm , computer graphics (images)
This study reports a DNA nanoswitch that can be used for visual display of outputs resulting from hybridization events of specific molecular inputs. Conformational changes of the DNA nanoswitch triggered by input DNA strands yield different “pixels” that collectively produce a graphical output on an agarose gel. This system has potential in molecular computation and biosensing approaches in which individual binding results can be translated into macromolecular visual readouts.