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Cover Feature: Alphanumerical Visual Display Made of DNA Logic Gates for Drug Susceptibility Testing of Pathogens (ChemBioChem 3/2018)
Author(s) -
Connelly Ryan P.,
Morozkin Evgeny S.,
Gerasimova Yulia V.
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800011
Subject(s) - deoxyribozyme , cover (algebra) , feature (linguistics) , g quadruplex , nucleic acid , dna , logic gate , chemistry , combinatorial chemistry , computer science , computational biology , biology , biochemistry , engineering , algorithm , mechanical engineering , linguistics , philosophy
The cover feature picture shows a seven‐segment display that produces alphanumerical characters in response to a specific nucleic acid fragment. The display is made of DNA‐based logic gates that produce a user‐friendly read‐out of the presence of a pathogen and its drug‐susceptibility signature. The design of the logic gates is based on a split G‐quadruplex peroxidase‐like deoxyribozyme that catalyzes the oxidation of a colorless organic molecule resulting in a colored product. The picture was prepared by Ivan Zaporozhchenko. More information can be found in the communication by Y. V. Gerasimova et al. on page 203 in Issue 3, 2018 (DOI: 10.1002/cbic.201700626).