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Screening for Selective Protein Inhibitors by Using the IANUS Peptide Array
Author(s) -
Erdmann Frank,
Prell Erik,
Jahreis Günther,
Fischer Gunter,
Malešević Miroslav
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700652
Subject(s) - nfat , dephosphorylation , peptide , computational biology , calcineurin , computer science , green fluorescent protein , chemistry , biochemistry , phosphorylation , world wide web , biology , gene , transcription factor , phosphatase , medicine , surgery , transplantation
Finding new road blacks : A peptidic inhibitor of calcineurin (CaN)‐mediated nuclear factor of activated T cells (NFAT) dephosphorylation, which is developed through a template‐assisted IANUS (Induced orgANisation of strUcture by matrix‐assisted togethernesS) peptide array, is cell permeable and able to block the translocation of green fluorescent protein–NFAT fusion protein (GFP‐NFAT) into the nucleus after stimulation.