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Induction of Signal Transduction by Using Non‐Channelrhodopsin‐Type Optogenetic Tools
Author(s) -
Ueda Yoshibumi,
Sato Moritoshi
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700635
Subject(s) - optogenetics , signal transduction , channelrhodopsin , transduction (biophysics) , synthetic biology , cell signaling , biology , neuroscience , microbiology and biotechnology , computational biology , biophysics
Signal transductions are the basis for all cellular functions. Previous studies investigating signal transductions mainly relied on pharmacological inhibition, RNA interference, and constitutive active/dominant negative protein expression systems. However, such studies do not allow the modulation of protein activity with high spatial and temporal precision in cells, tissues, and organs in animals. Recently, non‐channelrhodopsin‐type optogenetic tools for regulating signal transduction have emerged. These photoswitches address several disadvantages of previous techniques, and allow us to control a variety of signal transductions such as cell membrane dynamics, calcium signaling, lipid signaling, and apoptosis. In this review we summarize recent advances in the development of such photoswitches and in how these optotools are applied to signaling processes.