Control of Protein Activity and Gene Expression by Cyclofen‐OH Uncaging | Zendy

Zhang Weiting | Zendy; Hamouri Fatima | Zendy; Feng Zhiping | Zendy; Aujard Isabelle | Zendy; Ducos Bertrand | Zendy; Ye Shixin | Zendy; Weiss Shimon | Zendy; Volovitch Michel | Zendy; Vriz Sophie | Zendy; Jullien Ludovic | Zendy; Bensimon David | Zendy

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Control of Protein Activity and Gene Expression by Cyclofen‐OH Uncaging

Author(s) -

Zhang Weiting,

Hamouri Fatima,

Feng Zhiping,

Aujard Isabelle,

Ducos Bertrand,

Ye Shixin,

Weiss Shimon,

Volovitch Michel,

Vriz Sophie,

Jullien Ludovic,

Bensimon David

Publication year - 2018

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201700630

Subject(s) - context (archaeology) , fusion protein , ligand (biochemistry) , chemistry , microbiology and biotechnology , gene , computational biology , biophysics , biochemistry , receptor , biology , recombinant dna , paleontology

The use of light to control the expression of genes and the activity of proteins is a rapidly expanding field. Whereas many of these approaches use fusion between a light‐activable protein and the protein of interest to control the activity of the latter, it is also possible to control the activity of a protein by uncaging a specific ligand. In that context, controlling the activation of a protein fused to the modified estrogen receptor (ERT) by uncaging its ligand cyclofen‐OH has emerged as a generic and versatile method to control the activation of proteins quantitatively, quickly, and locally in a live organism. We present that approach and its uses in a variety of physiological contexts.

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