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Front Cover: Visualizing the Adenylation Activities and Protein–Protein Interactions of Aryl Acid Adenylating Enzymes (ChemBioChem 22/2017)
Author(s) -
Ishikawa Fumihiro,
Kasai Shota,
Kakeya Hideaki,
Tanabe Genzoh
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700566
Subject(s) - adenylylation , protein–protein interaction , protein function , aryl , front cover , cover (algebra) , chemistry , substrate (aquarium) , enzyme , biochemistry , function (biology) , combinatorial chemistry , computational biology , biology , microbiology and biotechnology , organic chemistry , biosynthesis , mechanical engineering , ecology , alkyl , engineering , gene
The cover picture shows protein–protein interactions between aryl acid carrier proteins (green) and aryl acid adenylation (A) domains (blue) that were visualized and assessed by using a new gel‐based strategy coupled with activity‐based probes. The substrate specificities of these A‐domains are also shown. This strategy should be immediately useful for assessing the nature of transient and specific CP–partner interactions and manipulating protein–protein interactions between non‐native pairs. More information can be found in the communication by F. Ishikawa et al. on page 2199 in Issue 22, 2017 (DOI: 10.1002/cbic.201700361).