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Regulating DNA Self‐assembly by DNA–Surface Interactions
Author(s) -
Liu Longfei,
Li Yulin,
Wang Yong,
Zheng Jianwei,
Mao Chengde
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700545
Subject(s) - dna , self assembly , nanotechnology , dna nanotechnology , biophysics , dna clamp , chemistry , chemical physics , materials science , biology , biochemistry , gene , polymerase chain reaction , reverse transcriptase
DNA self‐assembly provides a powerful approach for preparation of nanostructures. It is often studied in bulk solution and involves only DNA–DNA interactions. When confined to surfaces, DNA–surface interactions become an additional, important factor to DNA self‐assembly. However, the way in which DNA–surface interactions influence DNA self‐assembly is not well studied. In this study, we showed that weak DNA–DNA interactions could be stabilized by DNA–surface interactions to allow large DNA nanostructures to form. In addition, the assembly can be conducted isothermally at room temperature in as little as 5 seconds.