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Inside Cover: Traceless Cleavage of Protein–Biotin Conjugates under Biologically Compatible Conditions (ChemBioChem 17/2017)
Author(s) -
Cowell Joseph,
Buck Matthew,
Essa Ali H.,
Clarke Rebecca,
Vollmer Waldemar,
Vollmer Daniela,
Hilkens Catharien M.,
Isaacs John D.,
Hall Michael J.,
Gray Joe
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700432
Subject(s) - biotin , lysine , chemistry , stereochemistry , conjugate , combinatorial chemistry , biochemistry , amino acid , mathematical analysis , mathematics
The back cover picture shows RevAmine biotin tag‐modified (apo) cytochrome c (bovine) with two accessible lysine residues on the leftmost loop depicted as “ball and stick”. The upper‐left lysine is in neutral pH conditions (green background) and therefore still has the RevAmine tag attached, whereas the lower‐left lysine has been exposed to bicarbonate buffer, pH 8 (blue background with ions depicted) and as a consequence has tracelessly regenerated the residue along with free biotin and other by‐products. More information can be found in the communication by M. J. Hall, J. Gray et al. on page 1688 in Issue 17, 2017 (DOI: 10.1002/cbic.201700214).