Premium
Inside Back Cover: A Nonbactericidal Zinc‐Complexing Ligand as a Biofilm Inhibitor: Structure‐Guided Contrasting Effects on Staphylococcus aureus Biofilm (ChemBioChem 15/2017)
Author(s) -
Kapoor Vidushi,
Rai Rajanikant,
Thiyagarajan Durairaj,
Mukherjee Sandipan,
Das Gopal,
Ramesh Aiyagari
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700372
Subject(s) - biofilm , zinc , chemistry , ligand (biochemistry) , benzothiazole , staphylococcus aureus , cover (algebra) , chelation , microbiology and biotechnology , combinatorial chemistry , stereochemistry , biochemistry , biology , bacteria , organic chemistry , receptor , genetics , mechanical engineering , engineering
The inside back cover picture shows the divergent anti‐biofilm potentials of a thiosemicarbazone‐based zinc‐complexing ligand and a benzothiazole‐based one. Mechanistic studies provided a fundamental understanding of how the structural differences in these non‐bactericidal ligands had contrasting effects on the inhibition of biofilm growth (shown as a build up of blue spheres). This information could be used as a guide in designing compounds that would target the onset of staphylococcal biofilm formation. More information can be found in the full paper by G. Das, Aiyagari Ramesh, et al. on page 1502 in Issue 15, 2017 (DOI: 10.1002/cbic.201700139).