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Cover Picture: Cyclotides: Overview and Biotechnological Applications (ChemBioChem 14/2017)
Author(s) -
Gould Andrew,
Camarero Julio A.
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700333
Subject(s) - cover (algebra) , disulfide bond , computational biology , scaffold , chemistry , peptide , combinatorial chemistry , nanotechnology , computer science , biology , materials science , biochemistry , engineering , programming language , mechanical engineering
The cover picture shows a cyclotide, a globular microprotein with a unique head‐to‐tail cyclized backbone that is stabilized by three disulfide bonds forming a cystine‐knot motif. The high stability and sequence tolerance of this molecular scaffold have made it an excellent framework for the design of novel peptide‐based therapeutics and bioimaging tools. In their article, the authors provide an overview of the biotechnological applications of these interesting microproteins. Cover art produced by Isaac Mora. More information can be found in the review by J. A. Camarero and A. Gould on page 1350 in Issue 14, 2017 (DOI: 10.1002/cbic.201700153).