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Size Matters: Chemical Synthesis of a Homogenous Arabinogalactan 92‐mer
Author(s) -
Walczak Maciej A.,
Zhu Feng
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700311
Subject(s) - arabinogalactan , glycosylation , chemistry , oligosaccharide , chemical synthesis , stereochemistry , combinatorial chemistry , cell wall , organic chemistry , biochemistry , in vitro
31+30+31 : Ye and colleagues have synthesized a branched 92‐mer of arabinogalactan—a major component of the cell wall of M. tuberculosis— by linking a linear oligogalactan 30‐mer with two d ‐arabinofuranose 31‐mers. Their approach capitalizes on sequential, one‐pot glycosylation reactions that result in a rapid increase in molecular complexity and efficient synthesis of a branched oligosaccharide.