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Self‐Assembled Nano‐Immunostimulant for Synergistic Immune Activation
Author(s) -
Sun ZhanYi,
Chen PuGuang,
Liu YanFang,
Shi Lei,
Zhang BoDou,
Wu JunJun,
Zhao YuFen,
Chen YongXiang,
Li YanMei
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700246
Subject(s) - immunostimulant , immunopotentiator , immune system , adjuvant , immunotherapy , cancer immunotherapy , cancer , immunology , immunopharmacology , chemistry , cancer research , medicine
Immunotherapy has become one of the most promising therapies for the treatment of diseases. Synthetic immunostimulants and nanomaterial immunostimulant systems are indispensable for the activation of the immune system in cancer immunotherapy. Herein, a strategy for preparing self‐assembled nano‐immunostimulants (SANIs) for synergistic immune activation is reported. Three immunostimulants self‐assemble into nanoparticles through electrostatic interactions. SANIs showed strong synergistic immunostimulation in macrophages. SANIs could also induce a strong antitumor immune response to inhibit tumor growth in mice and act as an efficient adjuvant of antitumor vaccines. Therefore, SANIs may be generally applied in cancer immunotherapy. This novel SANI strategy provides a new way for the development of both immunostimulants and ‐suppressants.