Premium
Inside Cover: Selective Manipulation of Discrete Mannosidase Activities in the Endoplasmic Reticulum by Using Reciprocally Selective Inhibitors (ChemBioChem 11/2017)
Author(s) -
Kuribara Taiki,
Hirano Makoto,
Speciale Gaetano,
Williams Spencer J.,
Ito Yukishige,
Totani Kiichiro
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700243
Subject(s) - endoplasmic reticulum , glycan , chemistry , mannosidase , glycoprotein , iminosugar , secretion , microbiology and biotechnology , er retention , biochemistry , biology , enzyme , gene , mutant
The inside cover picture shows inhibitor‐based manipulation of glycoprotein sorting. Several α‐1,2‐mannosidases in the endoplasmic reticulum (ER) play important roles in producing signal glycoforms that control glyocprotein fate. With 1‐deoxymannojirimycin (dMJ), the glycan was selectively trimmed to the secretion signal in the ER fraction. On the other hand, glycan processing with 1‐deoxynojirimycin (dNJ) selectively produced the degradation signal. Overall, we have demonstrated dMJ and dNJ are available as traffic controllers in glycoprotein quality control. More information can be found in the full paper by K. Totani et al. on page 979 in Issue 11, 2017 (DOI: 10.1002/cbic.201700081).