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Back Cover: Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA‐Encoded Chemical Library Selections (ChemBioChem 9/2017)
Author(s) -
Li Yizhou,
Zimmermann Gunther,
Scheuermann Jörg,
Neri Dario
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700181
Subject(s) - dna , cover (algebra) , computational biology , genomic library , phage display , chemistry , combinatorial chemistry , nanotechnology , biology , computer science , microbiology and biotechnology , genetics , biochemistry , base sequence , engineering , antibody , materials science , mechanical engineering
The back cover picture shows how a ntibody phage display libraries and DNA‐encoded chemical libraries bear an obvious similarity. In both cases, large combinatorial libraries are selected for the discovery of binding molecules, which selectively recognize a target protein of interest. Once these molecules have been physically separated from the rest of the library (e.g., by capture on the protein of interest, immobilized on a solid support), they can be identified by the corresponding DNA tag (“genotype”). More information can be found in the communication by D. Neri et al. on page 848 in Issue 9, 2017 (DOI: 10.1002/cbic.201600626).