Premium
Inside Cover: Enantioselective Reduction of Citral Isomers in NCR Ene Reductase: Analysis of an Active‐Site Mutant Library (ChemBioChem 8/2017)
Author(s) -
Kress Nico,
Rapp Johanna,
Hauer Bernhard
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700163
Subject(s) - citral , citronellal , chemistry , stereochemistry , active site , ene reaction , aroma , mutagenesis , mutant , biochemistry , enzyme , catalysis , food science , essential oil , gene
The inside cover picture shows the ene reductase NCR as a “lemon press” converting either the ( E )‐ or the ( Z )‐citral isomer to citronellal juice. Tryptophan residue 66 (marked in orange) or the alanine counterpart (red) at this position decides whether the juice contains ( S )‐ or ( R )‐citronellal. The development of an R ‐selective citral reduction catalyst is of industrial importance for the synthesis of aroma chemicals such as (−)‐menthol. The active‐site‐mutagenesis study presented in this paper reveals an important discrimination of the citral isomers by NCR ene reductase More information can be found in the communication by B. Hauer et al. on page 717 in Issue 8, 2017 (DOI: 10.1002/cbic.201700011).