Back Cover: An Exceptionally Selective DNA Cooperatively Binding Two Ca 2+  Ions (ChemBioChem 6/2017) | Zendy

Zhou Wenhu | Zendy; Saran Runjhun | Zendy; Huang PoJung Jimmy | Zendy; Ding Jinsong | Zendy; Liu Juewen | Zendy

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Back Cover: An Exceptionally Selective DNA Cooperatively Binding Two Ca 2+ Ions (ChemBioChem 6/2017)

Author(s) -

Zhou Wenhu,

Saran Runjhun,

Huang PoJung Jimmy,

Ding Jinsong,

Liu Juewen

Publication year - 2017

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201700087

Subject(s) - cleave , deoxyribozyme , dna , cover (algebra) , cleavage (geology) , chemistry , ion , calmodulin , rna , biophysics , stereochemistry , crystallography , enzyme , biochemistry , biology , gene , mechanical engineering , paleontology , organic chemistry , fracture (geology) , engineering

The back cover picture shows an RNA‐cleaving DNAzyme that uses two Ca 2+ ions cooperatively to cleave its substrate in a highly efficient manner; the same enzyme can also use just one Mg 2+ ion, but in this case the cleavage rate is nearly 100 times slower. This represents the best DNA so far for recognizing Ca 2+ over Mg 2+ , its cooperative binding being reminiscent of calmodulin, a Ca 2+ binding protein. More information can be found in the communication by J. Liu et al. on page 518 in Issue 6, 2017 (DOI: 10.1002/cbic.201600708).

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