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Inside Cover: Improving the Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells (ChemBioChem 4/2017)
Author(s) -
Tachibana Ryo,
Terai Takuya,
Boncompain Gaelle,
Sugiyama Shigeru,
Saito Nae,
Perez Franck,
Urano Yasuteru
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201700035
Subject(s) - streptavidin , solubility , treasure , chemistry , front cover , combinatorial chemistry , nanotechnology , biotin , cover (algebra) , materials science , biochemistry , organic chemistry , engineering , philosophy , mechanical engineering , theology
The inside cover picture shows an improvement in the solubility of artificial ligands of streptavidin (ALiS). The previously reported compound, ALiS‐1 ( ninja at front), cannot access streptavidin (SAv, gold treasure) in cells because of poor water solubility in the absence of organic cosolvent such as DMSO ( samurai ). On the other hand, the new compound, ALiS‐3 (the other ninja ), has higher solubility in water and can reach SAv inside cells; this is represented by his tricky art of escape from the samurai by using water ( suiton‐no‐jutsu ). Picture by R.T. More information can be found in the communication by Takuya Terai, Yasuteru Urano et al. on page 358 in Issue 4, 2017 (DOI: 10.1002/cbic.201600640).