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Enzymes Beat Chemists in the Formation of an Unnatural Bond
Author(s) -
Ducharme Julie,
Auclair Karine
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600692
Subject(s) - organosilicon , silanes , chemistry , enzyme , carbene , stereochemistry , catalysis , biochemistry , organic chemistry , silane
A fundamental difference? A heme protein known to catalyze electron transfers was engineered into an enzyme that catalyzes the formation of C−Si bonds with >99 % ee . The new enzyme uses diazoesters as carbene donors for the insertion of various silanes into the Si−H bond. This is the first reported organosilicon‐producing enzyme.