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Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates
Author(s) -
Villadsen Klaus,
MartosMaldonado Manuel C.,
Jensen Knud J.,
Thygesen Mikkel B.
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600582
Subject(s) - glycoconjugate , glycobiology , glycomics , chemistry , anomer , glycolipid , biochemistry , function (biology) , biology , glycan , glycoprotein , microbiology and biotechnology
Glycobiology is the comprehensive biological investigation of carbohydrates. The study of the role and function of complex carbohydrates often requires the attachment of carbohydrates to surfaces, their tagging with fluorophores, or their conversion into natural or non‐natural glycoconjugates, such as glycopeptides or glycolipids. Glycobiology and its “omics”, glycomics, require easy and robust chemical methods for the construction of these glycoconjugates. This review gives an overview of the rapidly expanding field of chemical reactions that selectively convert unprotected carbohydrates into glycoconjugates through the anomeric position. The discussion is divided in terms of the anomeric bond type of the newly formed glycoconjugates, including O‐, N‐, S‐, and C‐glycosides.