Premium
Inside Cover: Antibiotic Potency against E. coli Is Enhanced by Channel‐Forming Alkyl Lariat Ethers (ChemBioChem 22/2016)
Author(s) -
Negin Saeedeh,
Patel Mohit B.,
Gokel Michael R.,
Meisel Joseph W.,
Gokel George W.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600569
Subject(s) - efflux , ether , chemistry , alkyl , cover (algebra) , potency , combinatorial chemistry , antibiotics , stereochemistry , organic chemistry , biochemistry , in vitro , engineering , mechanical engineering
The inside cover picture shows the proposed mechanism for our lariat ether′s ability to both enhance antibiotic efficacy and overcome efflux‐pump based antibiotic resistance. The pictured chemical structure is an aggregate model of five lariat ether compounds present in the cell membrane. More information can be found in the full paper by G. W. Gokel et al. on page 2153 in Issue 22, 2016 (DOI: 10.1002/cbic.201600428).