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Achievements, Challenges, and Opportunities in DNA‐Encoded Library Research: An Academic Point of View
Author(s) -
Yuen Lik Hang,
Franzini Raphael M.
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600567
Subject(s) - drug discovery , identification (biology) , drug development , engineering ethics , computational biology , nanotechnology , data science , computer science , chemistry , biology , drug , engineering , bioinformatics , pharmacology , botany , materials science
DNA‐encoded chemical libraries (DECLs) are pools of DNA‐tagged small molecules that enable facile screening and identification of bio‐macromolecule binders. The successful development of DECLs has led to their increasingly important role in drug development, and screening hits have entered clinical trials. In this review, we summarize the development and currently active research areas of DECLs with a focus on contributions from groups at academic institutes. We further look at opportunities and future directions of DECL research in medicinal chemistry and chemical biology based on the symbiotic relationship between academia and industry. Challenges associated with the application of DECLs in academic drug discovery are further discussed.