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Tetrazine‐Responsive Self‐immolative Linkers
Author(s) -
Neumann Kevin,
Jain Sarthak,
Gambardella Alessia,
Walker Sarah E.,
Valero Elsa,
Lilienkampf Annamaria,
Bradley Mark
Publication year - 2017
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600560
Subject(s) - tetrazine , linker , chemistry , context (archaeology) , small molecule , molecule , combinatorial chemistry , bioorthogonal chemistry , doxorubicin , nanotechnology , biophysics , biochemistry , click chemistry , materials science , organic chemistry , computer science , medicine , paleontology , surgery , chemotherapy , biology , operating system
Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.