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Engineering Protein Self‐Assembly: A New Approach for the Design of Octahedral Cages
Author(s) -
Coug Fabien B. L.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600526
Subject(s) - octahedron , protein engineering , self assembly , protein design , nanostructure , nanotechnology , symmetry (geometry) , chemistry , protein structure , crystallography , materials science , biochemistry , crystal structure , mathematics , enzyme , geometry
A new symmetry‐based approach allowed the self‐assembly of an octahedral protein nanostructure. C 3 trimeric and C 4 tetrameric oligomerization domains can be combined in an engineered protein to direct assembly into a desired object. This work might provide the basis for a more general and flexible strategy to control protein self‐assembly.