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Inside Cover: Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty‐Acylated Proteins (ChemBioChem 19/2016)
Author(s) -
Thi Emmanuelle,
Percher Avital,
Hang Howard C.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600500
Subject(s) - bioorthogonal chemistry , chemistry , oleic acid , fatty acid , covalent bond , biochemistry , unsaturated fatty acid , proteomics , click chemistry , organic chemistry , gene
The inside cover picture shows that oleic acid, a dietary mono‐unsaturated fatty acid notably found in olive oil, can be covalently added to many proteins in cells. We synthesized alkyne‐tagged unsaturated fatty acid chemical reporters and determined their protein targets in mammalian cells by quantitative proteomics analysis. We show that unsaturated fatty acids modify similar protein targets to saturated fatty acids, including several immunity‐associated proteins; this demonstrates how unsaturated fatty acids can directly modify many proteins to exert their unique and often beneficial physiological effects in vivo. More information can be found in the communication by H. C. Hang et al. on page 1800 in Issue 19, 2016 (DOI: 10.1002/cbic.201600213).