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A New Caged‐Glutamine Derivative as a Tool To Control the Assembly of Glutamine‐Containing Amyloidogenic Peptides
Author(s) -
Awad Loay,
Jejelava Nino,
Burai Ritwik,
Lashuel Hilal A.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600474
Subject(s) - glutamine , chemistry , derivative (finance) , biochemistry , combinatorial chemistry , amino acid , financial economics , economics
We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can be used to develop molecular switches to control the folding and β‐sheet formation of amyloidogenic peptides.