Premium
Inside Cover: Biosynthetic Gene Cluster for Surugamide A Encompasses an Unrelated Decapeptide, Surugamide F (ChemBioChem 18/2016)
Author(s) -
Ninomiya Akihiro,
Katsuyama Yohei,
Kuranaga Takefumi,
Miyazaki Masayuki,
Nogi Yuichi,
Okada Shigeru,
Wakimoto Toshiyuki,
Ohnishi Yasuo,
Matsunaga Shigeki,
Takada Kentaro
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600458
Subject(s) - gene cluster , gene , biosynthesis , stereochemistry , peptide , cover (algebra) , cyclic peptide , chemistry , cluster (spacecraft) , biology , biochemistry , mechanical engineering , computer science , engineering , programming language
The inside cover picture shows that one NRPS cluster produces two unrelated classes of peptide. Two NRPS genes, surA and surD (red), for the cyclic octapeptides surugamides A–E are separated by two different NRPS genes, surB and surC (yellow). The latter genes are responsible for the biosynthesis of an unrelated linear decapeptide, surugamide F. The pattern of intercalation observed in the sur genes is unprecedented. More information can be found in the communication by S. Matsunaga, K. Takada et al. on page 1709 in Issue 18, 2016 (DOI: 10.1002/cbic.201600350).