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Inside Cover: Exploring the Potential of Norbornene‐Modified Mannosamine Derivatives for Metabolic Glycoengineering (ChemBioChem 14/2016)
Author(s) -
Späte AnneKatrin,
Dold Jeremias E. G. A.,
Batroff Ellen,
Schart Verena F.,
Wieland Daniel E.,
Baudendistel Oliver R.,
Wittmann Valentin
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600355
Subject(s) - bioorthogonal chemistry , tetrazine , chemistry , monosaccharide , glycan , cover (algebra) , combinatorial chemistry , biochemistry , click chemistry , organic chemistry , glycoprotein , engineering , mechanical engineering
The inside cover picture shows how metabolic glycoengineering can be explained in a creative way (idea: Sven Epple). Modified monosaccharides are used to engineer the cell surfaces’ glycans with functional groups. Surprisingly, bulky norbornenes can also be used as modifiers. In a second step, these modifications are “colored” through a bioorthogonal ligation reaction with a tetrazine or cyclooctyne that is linked to a label. More information can be found in the full paper by V. Wittmann et al. on page 1374 in Issue 14, 2016 (DOI: 10.1002/cbic.201600197).