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Cover Picture: Reduction‐Responsive Guanine Incorporated into G‐Quadruplex‐Forming DNA (ChemBioChem 14/2016)
Author(s) -
Ikeda Masato,
Kamimura Masahiro,
Hayakawa Yukiko,
Shibata Aya,
Kitade Yukio
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600354
Subject(s) - oligonucleotide , nucleobase , guanine , g quadruplex , dna , chemistry , biomolecule , combinatorial chemistry , reduction (mathematics) , computational biology , biochemistry , biology , nucleotide , gene , geometry , mathematics
The cover picture shows the reduction‐responsive structural transition of an oligonucleotide bearing a newly designed chemically reactive nucleobase (G NB ) from random‐coil to G‐quadruplex structure. Stimuli‐responsive oligonucleotides are attractive targets for understanding the behaviour of biomolecules as well as for exploring their therapeutic and diagnostic applications. We have demonstrated that a reduction‐responsive cleavable group, 4‐nitrobenzyl (NB), introduced into a guanine nucleobase modulates the secondary structural transition of an oligonucleotide in a reduction‐responsive and traceless manner. This simple but robust strategy will provide important chemical tools for developing stimuli‐responsive oligonucleotides. More information can be found in the communication by M. Ikeda, Y. Kitade, et al. on page 1304 in Issue 14, 2016 (DOI: 10.1002/cbic.201600164).