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Cover Picture: DNA Origami Seesaws as Comparative Binding Assay (ChemBioChem 12/2016)
Author(s) -
Nickels Philipp C.,
Høiberg Hans C.,
Simmel Stephanie S.,
Holzmeister Phil,
Tinnefeld Philip,
Liedl Tim
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600307
Subject(s) - cover (algebra) , dna , dna origami , nanoscopic scale , nanotechnology , chemistry , computational biology , biology , materials science , biochemistry , engineering , mechanical engineering
The cover picture shows the concept of a nanoscopic weighing balance, which is used to measure differences in binding energy. The hybridization of competing DNA binding pairs was studied by using a self‐assembled DNA origami structure that acts as such a nanoscopic weighing balance. Changing the relative binding energies of the DNA binding pairs tips the scale towards the side with the higher number of hybridized DNA duplexes. Image by Christoph Hohmann, Nanosystems Initiative Munich (NIM). More information can be found in the communication by P. C. Nickels, T. Liedl et al. on page 1093 in Issue 12, 2016 (DOI: 10.1002/cbic.201600059).