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Inside Cover: The Anticancer Activity of Organotelluranes: Potential Role in Integrin Inactivation (ChemBioChem 10/2016)
Author(s) -
Silberman Alon,
Kalechman Yona,
Hirsch Shira,
Erlich Ziv,
Sredni Benjamin,
Albeck Am
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600250
Subject(s) - cover (algebra) , in vitro , in vivo , cysteine , chemistry , integrin , biochemistry , cancer research , computational biology , biology , receptor , genetics , enzyme , mechanical engineering , engineering
The inside cover picture shows a class of synthetic organic Te IV compounds (organotelluranes) that have been discovered by us to target the VLA‐4 integrin on cancer cells. The organotelluranes interact with cysteine residues in VLA‐4 through the substitution of their labile ligands, resulting in the inactivation of VLA‐4 and the ensuing malignant functions in vitro, and in suppression of metastases development in vivo. More information can be found in the full paper by B. Sredni, A. Albeck, et al. on page 918 in Issue 10, 2016 (DOI: 10.1002/cbic.201600614).