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Cover Picture: Fine‐Tuning Covalent Inhibition of Bacterial Quorum Sensing (ChemBioChem 9/2016)
Author(s) -
Amara Neri,
Gregor Rachel,
Rayo Josep,
Dandela Rambabu,
Daniel Erik,
Liubin Nina,
Willems H. Marjo E.,
BenZvi Anat,
Krom Bastiaan P.,
Meijler Michael M.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600232
Subject(s) - quorum sensing , covalent bond , homoserine , cover (algebra) , chemistry , pseudomonas aeruginosa , electrophile , combinatorial chemistry , regulator , nanotechnology , bacteria , biochemistry , biology , materials science , organic chemistry , gene , virulence , genetics , mechanical engineering , engineering , catalysis
The cover picture shows schematically how the important quorum‐sensing regulator LasR of the human pathogen Pseudomonas aeruginosa can be targeted with tailor‐made covalent probes. A diverse array of electrophile‐containing N‐acylated homoserine lactones was prepared and evaluated for their ability to covalently modify LasR. Striking differences in activity were observed between the halogenated isothiocyanates. More information can be found in the full paper by M. M. Meijler et al on page 825 in Issue 9, 2016 l. (DOI: 10.1002/cbic.201500676).