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Thiol Redox and p K a Properties of Mycothiol, the Predominant Low‐Molecular‐Weight Thiol Cofactor in the Actinomycetes
Author(s) -
Sharma Sunil V.,
Van Laer Koen,
Messens Joris,
Hamilton Chris J.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600228
Subject(s) - thiol , redox , cofactor , chemistry , cysteine , biochemistry , stereochemistry , enzyme , organic chemistry
The thiol p K a and standard redox potential of mycothiol, the major low‐molecular‐weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.