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Inside Cover: A CatalyCEST MRI Contrast Agent that Can Simultaneously Detect Two Enzyme Activities (ChemBioChem 5/2016)
Author(s) -
FernándezCuervo Gabriela,
Sinharay Sanhita,
Pagel Mark D.
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600080
Subject(s) - cleave , chemistry , salicylic acid , small molecule , mri contrast agent , cover (algebra) , magnetic resonance imaging , esterase , nuclear magnetic resonance , enzyme , biochemistry , gadolinium , organic chemistry , physics , mechanical engineering , engineering , medicine , radiology
The inside cover picture shows a new contrast agent for multiplexed detection of enzyme activities. When esterase (blue) and sulfatase (green) cleave the ligands of the contrast agent, the agent is converted to salicylic acid. The product has a proton that can exchange with protons on water molecules, and this can be detected through chemical exchange saturation transfer magnetic resonance imaging (CEST MRI). Because MRI can generate outstanding images of soft tissues (as shown in the picture), this “smart” contrast agent has potential to improve molecular imaging. More information can be found in the communication by M. D. Pagel et al. on page 383 in Issue 5, 2016 (DOI: 10.1002/cbic.201500586).