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In‐Phase Assembly of Slim DNA Lattices with Small Circular DNA Motifs via Short Connections of 11 and 16 Base Pairs
Author(s) -
Wang Meng,
Guo Xin,
Jiang Chuan,
Wang Xuemei,
Xiao ShouJun
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600054
Subject(s) - antiparallel (mathematics) , tile , base pair , oligonucleotide , crystallography , dna nanotechnology , dna , curvature , materials science , chemistry , physics , stereochemistry , mathematics , geometry , composite material , biochemistry , quantum mechanics , magnetic field
Abstract Two kinds of stable motif were constructed: SAE (semi‐crossover, antiparallel, even half‐turns) tile from one small circular DNA molecule (42 or 64 nt) and two linear oligonucleotides; and DAE (double‐crossover, antiparallel, even half‐turns) tile from one small circular DNA molecule (42 or 64 nt) and four linear oligonucleotides. With the SAE tiles, in‐phase assembly of SAE–E (SAE tiles with even half‐turns as connections (–E)) with the shortest –E of 11 base pairs (bp) generated homogeneous nanotubes with an average length of over 14 μm and a diameter of 16–20 nm; with the DAE tiles, in‐phase assembly of DAE–O (DAE tiles with odd half‐turns as connections (–O)) with the shortest –O of 16 bp produced slim monolayer nanoyarns (25–30 nm wide), nanoscarfs (100–300 nm wide), and nanoribbons (∼100 nm wide). Interestingly, a phenomenon we term “knitting nanoyarns” into nanoscarfs was observed. Finally a curvature mechanism according to the ring rotation directions is suggested to explain the formation of nanotubes, wavy nanoyarns, nanoscarfs, and nanoribbons.