Premium
DNA Walker‐Regulated Cancer Cell Growth Inhibition
Author(s) -
Li Feiran,
Cha TaeGon,
Pan Jing,
Ozcelikkale Altug,
Han Bumsoo,
Choi Jong Hyun
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600052
Subject(s) - oligonucleotide , deoxyribozyme , cancer cell , dna , nanotechnology , extracellular matrix , chemistry , cell growth , cancer , biophysics , microbiology and biotechnology , biology , biochemistry , materials science , genetics
We demonstrate a DNAzyme‐based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.