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Inside Cover: Onocerin Biosynthesis Requires Two Highly Dedicated Triterpene Cyclases in a Fern Lycopodium clavatum (ChemBioChem 4/2016)
Author(s) -
Araki Takeshi,
Saga Yusuke,
Marugami Momo,
Otaka Junnosuke,
Araya Hiroshi,
Saito Kazuki,
Yamazaki Mami,
Suzuki Hideyuki,
Kushiro Tetsuo
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600030
Subject(s) - fern , biosynthesis , substrate (aquarium) , triterpene , stereochemistry , lycopodium , substrate specificity , chemistry , cover (algebra) , enzyme , botany , biology , biochemistry , medicine , mechanical engineering , alternative medicine , pathology , engineering , ecology
The inside cover picture shows the biosynthesis of an unique symmetrical triterpene α‐onocerin produced by a fern Lycopodium sp. Two genes, LCC and LCD, were identified that belong to oxidosqualene cyclase (OSC) family. LCC exclusively utilized dioxidosqualene (top) as a substrate to produce a half cyclized intermediate pre‐a‐onocerin (middle) which was then taken up by LCD to produce α‐onocerin (bottom). The substrate specificity of these enzymes was significantly different from known OSC family that uncovered the potential ability of this family to catalyze even more different reactions. More information can be found in the communication by T. Kushiro et al. on page 288 in Issue 4, 2016 (DOI: 10.1002/cbic.201500663).