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Inside Cover: One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites (ChemBioChem 11/2015)
Author(s) -
Fischer Marcus,
Shoichet Brian K.,
Fraser James S.
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201590029
Subject(s) - cover (algebra) , transient (computer programming) , ligand (biochemistry) , crystallography , chemistry , cytochrome , nanotechnology , materials science , computer science , receptor , biochemistry , engineering , mechanical engineering , operating system , enzyme
The inside cover picture shows a song of ice and fire for cytochrome c peroxidase. By changing the crystallographic data collection temperature, J. S. Fraser and co‐workers (p. 1560 ff.) were able to “unlock” cryptic sites that are often difficult to visualize. The key represents benzimidazole, which occupied the cryptic site only at room temperature (red) and was hidden at cryogenic temperature.