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Inside Cover: A Peptide‐Functionalized Polymer as a Minimal Scaffold Protein To Enhance Cluster Formation in Early T Cell Signal Transduction (ChemBioChem 4/2015)
Author(s) -
Witsenburg J. Joris,
Sinzinger Michael D.,
Stoevesandt Oda,
Ruttekolk Ivo R.,
Roth Günter,
AdjoboHermans Merel J. W.,
Brock Roland
Publication year - 2015
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201590006
Subject(s) - jurkat cells , scaffold protein , chemistry , methacrylamide , scaffold , peptide , signal transduction , protein–protein interaction , biophysics , t cell , biochemistry , monomer , biology , polymer , medicine , acrylamide , immune system , organic chemistry , biomedical engineering , immunology
The inside cover picture shows Jurkat T cells treated with a synthetic scaffold protein, consisting of an N ‐(2‐hydroxypropyl)methacrylamide polymer backbone and SH3‐domain‐binding peptides corresponding to a proline‐rich domain of the T cell signaling protein SLP76. On p. 602 ff., R. Brock and co‐workers explain how incubation of these cells on CD3‐ and CD28‐stimulating microspots (blue) enhanced microcluster formation of the signaling protein GADS (red).